Your genes play a major role in determining your height, hair and eye color, and skin tone, but they don’t tell the entire story of who you are. Your environment is incredibly important in shaping your personality, your likes and dislikes, and your health. In fact, your diet, social interactions, exposure to pollution, physical activity and education often exceed the influence of genetics on many of the features that define you.
Figuring out how your genes and environment increase your likelihood of developing asthma, heart disease, cancer, dementia and other conditions can have life-changing consequences. The field of genomics has made it relatively straightforward to test both in the hospital and at home for a wide range of genetic variations linked to disease risk.
And in recent years, science has been making progress on tracking down the environmental culprits that drive risk for several diseases – and on identifying ways to optimize treatments based on your personal environmental exposures.
Prescribing the most effective treatment from the get-go can reduce harmful drug reactions.
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My work as a pharmacologist and toxicologist has led me to the emerging science of exposomics – the study of all of the physical, chemical, biological and social factors that affect your biology. While your genome comprises all of the genes that encode your biology, your exposome is a concept that comprises all your environmental exposures. Like how researchers use DNA sequencers to study genomics, scientists in exposomics use chemistry and high-tech sensors to measure the effects of thousands of environmental factors on health.
Medications don’t always work
For many people, standard drug therapies to treat certain conditions simply don’t work. Controlling blood pressure often requires months of trial and error. It can take months or even years to identify an adequate treatment plan for depression.
Adverse events caused by medications account for more than 1 million visits to emergency departments each year in the U.S. What drives these differences in drug effects between patients? Is it their genes? Are they not taking their medication as prescribed due to side effects? Or something else?
As it turns out, your environment can have a major effect on how well specific treatments work for you. Think about the warning labels advising you not to drink grapefruit juice while taking a specific drug, for example. This is because a natural chemical in grapefruit inhibits the enzymes that break down those medications. Some common statins used to control high cholesterol can build up to toxic levels because the chemical in grapefruit juice blocks its normal processing.
Grapefruit isn’t the only environmental factor affecting how you respond to your medications. Over 8,600 chemicals are used in commerce in the U.S., and you are exposed to thousands of these…