Red 3 – also called FD&C Red No. 3, erythrosine or E127 – has been widely used in food, cosmetics and pharmaceuticals since its FDA approval in 1969. You’ve likely encountered Red 3 before. It’s a common additive to many candies, beverages, baked goods, cereals, maraschino cherries and gelatin desserts, as well as certain medications, syrups and cosmetics.
However, mounting scientific evidence suggests that consuming Red 3 poses significant health risks. These risks prompted California to ban its use in food in 2023 and the Food and Drug Administration to ban its use in both food and pharmaceuticals nationwide on Jan. 15, 2025.
As a researcher studying inflammation and cancer, I investigate how synthetic food dyes affect human health. Stricter regulations reflect growing concerns over the negative physiological effects of Red 3 and other synthetic dyes on your body, including causing cancer.
Health risks of Red 3
Over the past 35 years, an increasing amount of scientific evidence has identified the negative health effects of Red 3. While researchers haven’t yet established a direct link between Red 3 and cancer in people, substantial evidence from animal studies points to its carcinogenic potential.
First, Red 3 disrupts thyroid hormone regulation through several mechanisms. It inhibits the thyroid gland’s ability to absorb iodine, a key component for synthesizing thyroid hormones, and blocks an enzyme essential for converting one thyroid hormone to another, contributing to thyroid dysfunction. Along with other impairments in thyroid hormone function, Red 3 increases the risk of thyroid-related disorders.
Several animal studies have linked Red 3 to thyroid dysfunction and cancer.
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Second, Red 3 may promote thyroid tumor formation. Several studies exposing rats and pigs to Red 3 observed enlarged tumorous thyroid glands and abnormalities in hormone regulation.
Third, Red 3 can have toxic effects on the brain in multiple ways. Rat studies have found that this synthetic dye increases oxidative stress, which damages tissues, and reduces the antioxidants that control oxidative stress, impairing communication between neurons. Studies in rodents also found that Red 3 triggers neuroinflammation that leads to neuronal damage and dysfunction. Additionally, Red 3 may interact with the amyloid-beta peptides linked to neurodegenerative conditions like Alzheimer’s disease and worsen those conditions.
Regulatory momentum
Red 3 first faced scrutiny in the 1980s when several animal studies linked it to thyroid tumors in male rats. This led to its 1990 ban in cosmetics in the U.S., although its use in food persisted under industry pressure. While the European Union restricted the use of Red 3 to only certain types of processed cherries in 1994, the U.S. has lagged behind.
California’s 2023 ban of Red 3 in foods, effective in 2027, reignited…