Should pregnant women get the COVID-19 vaccine? Will it protect against asymptomatic infections and mutated viruses? An immunologist answers 3 questions
This week I was vaccinated against COVID-19 with the Pfizer mRNA vaccine, which brought to mind some frequently asked questions about the Pfizer and Moderna vaccines.
I am a professor of infectious diseases at the University of Virginia, where I care for patients with COVID-19 and conduct research on how best to prevent, diagnose and treat this new infection. As I interact with patients in the hospital, some mothers and expectant mothers have asked whether it is safe for them to take the vaccine. Here is what I have said to them.
1) Can I get vaccinated if I am pregnant or breastfeeding?
Yes, you can and should get a COVID-19 vaccine if you are either pregnant or breastfeeding.
Neither the Pfizer nor Moderna COVID-19 vaccine contains the live SARS-CoV-2 virus, so there is no risk of the pregnant woman or her fetus developing COVID-19. These vaccines are safe for another reason. The mRNA used in both vaccines to stimulate a protective immune response never enters the nucleus of a cell. That means it doesn’t interact with the DNA that encodes the human genome of the mother or fetus.
The caveat is that safety data is lacking for the COVID-19 vaccines, because pregnant women were intentionally excluded in the phase 3 studies of the Moderna and Pfizer vaccines.
In the absence of clinical trial data on the Pfizer and Moderna vaccines in pregnant and breastfeeding women, but with the expectation that these vaccines should be safe in these populations, both the CDC
and the American College of Obstetricians and Gynecologists have recommended that vaccination be a personal decision of women who are pregnant.
For pregnant women who decide to be vaccinated, any fever associated with vaccination should be treated with acetaminophen, since fever has been associated with adverse pregnancy outcomes.
2) Will I be protected from asymptomatic infection?
Initial data shows 60% protection from asymptomatic infection after the first dose of the Moderna mRNA vaccine. It is likely Pfizer will also protect from asymptomatic infection, but this has not yet been shown. This means that your risk of getting an asymptomatic infection is reduced by more than half after the first dose of the Moderna vaccine.
Subjects in the phase 3 study had nasal swabs taken at the time of the second dose of the vaccine. Of these, 14 of the 15,000 volunteers in the vaccine group and 38 of 15,000 subjects in the placebo group experienced SARS-CoV-2 infection without symptoms – which is called asymptomatic COVID-19.
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This is evidence that asymptomatic infections are being prevented even after only the first dose. This is wonderful news, as vaccine-induced protection from asymptomatic infection will facilitate herd immunity and the end of the pandemic.
3) Will new versions of the SARS-CoV-2 virus succumb to the vaccine?
The primary way that these vaccines act is by preventing the spike protein on the exterior of the coronavirus from attaching to the ACE2 protein on human cells.
The vaccines do this by triggering the human immune system to produce anti-spike antibodies that attach to the spike protein whenever they encounter it and neutralize the virus.
All 17 versions of the virus tested so far have been neutralized, including the variant that is most common in the United States.
The new variant in the United Kingdom that is likely more easily spread person to person is also unlikely to evade the new vaccines, despite the presence of mutations in the spike glycoprotein. This is in part due to the fact that there are multiple sites on the spike protein that antibodies can target to neutralize the virus. This is being formally tested now.